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Cooperation

 

 

 

 

 

 

Examples of cooperation : 

   www.safetypharmacology.org/cipa/Vargas_CIPA.pdf

SPS 2015 poster

  SPS 2016 poster 

 Nova Research Laboratories LLC  Research article

 

 

Based on the algorithms already validated in the scientific literature, Safe Cardiac Action Potential Test (SCAP Test) can identify some drug cardiac liabilities (such as early after depolarisation (EAD), triangulation, reverse use dependence (RUD), transmural dispersion of repolarisation (TDR), action potential duration (APD) prolongation or shortening, Vmax increase or decrease,....) on various cellular types (such as Purkinje fibre, atrial or ventricular myocytes,..) of different species (such as guinea pig, rabbit, dog, human) under various experimental conditions (such as cycle length, ionic composition, inhibition or activation of various ionic currents..)

 

If you want to set up a cooperation for any study (for publication for example), don't hesitate to contact us using the contact form or the following email  (bchristophe@scaptest.com).  You will receive a reply as soon as possible

 

Available models:

            Ventricular Myocyte                          Purkinje Fibre Cell                             Atrial myocyte             
  Guinea pig      

    Luo & Rudy (1994)

Circ Res 74: 1071-1096  

       ---------      ---------
  Rabbit

    Shannon & al. (2004)

Biophys J  87: 3351-3371  

      Aslanidi & al. (2010)

Biophys J  98: 2420-2431  

     Aslanidi & al. (2009)

Biophys J  96: 798-817  
  Dog

    Hund & Rudy (2004)

Circulation  110:  3168-3174  

      Aslanidi & al. (2009)

Biophys J  97: 20-39   

    Xia & al. (2010)  

J Zhejiang Univ-Sci B 11:402-416  
  Human

    Grandi & al.  (2010)

J Mol Cell Cardiol  48:  112-121  

    O'Hara & al. (2011)

PLoS Comput Biol  7: e1002061  

      Stewart & al.  (2009)

Philos Trans A Math Phys Eng Sci  367: 2225-2255  

      Sampson & al. (2010)

J Physiol 588: 2643-2655  

    Maleckar & al. (2008)

Prog Biophys Mol Biol 98: 161-170  

 

 Parameters that can be tested on each model:

  • Various levels of inhibition or activation of various channels, individually or simultaneously

                     (INa  INaL  INab  IKr  Iks  IK1  Ito  IKb  ICaL  ICaT ICaNa  ICaK  ICab  INaCa INaK  IpCa  .......)

  • Various stimulation rates
  • Various [Na+]e, [K+]e and/or [Ca++]e

 

Results expressed as

  • AP parameters (RMP, APA, Vmax, APD40, APD60, APD90, T40, T60….)
  • Cardiac markers (EAD, TDR, RUD, APD prolongation or shortening, Triangulation, Vmax increase or decrease, ....)