Cardiac action potential simulation
In line with the CiPA initiative,
this site helps you to determine
the cardiac safety profile of drugs
using in silico cardiac action potential simulation
based on search for:
Early afterdepolarization facilitation (EAD)
Transmural dispersion of repolarization (TDR)
Reverse use dependence (RUD)
Triangulation
Action potential duration (APD) : prolongation or shortening
Maximal rate of AP rise: Vmax increase or decrease
qNet (integration sum of ICaL+IKr+IKs+INaL+Ito+IK1)
Vmin (minimal rate of AP decrease at the EAD take-off voltage)
At the time being, 200 drugs are described regarding their in silico cardiac safety profile:
(please sign in for free in order to see the safety profile of each drug)
Ajmaline, Alfuzosin, Almokalant, Alosetron, Alvimopan, Ambrisentan, Amiodarone, Amitriptyline, Amlodipine, Aprindine, Asenapine, Aspirin, Astemizole, Atenolol, Atomoxetine, Azimilide, Azithromycin, Bedaquiline, Bepridil, Bosutinib, Bupivacaine, Carbamazepine, Carvedilol, Ceftriaxone, Ceritinib, Cetirizine, Chloroquine, Chlorpheniramine, Chlorpromazine, Cibenzoline, Cilostazol, Ciprofloxacin, Cisapride, Citalopram, Clarithromycin, Clomipramine, Clozapine, Crizotinib, Darifenacin, Darunavir, Dasabuvir, Dasatinib, Deferasirox, Desipramine, Desvenlafaxine, Diazepam, Diltiazem, Digoxin, Diphenhydramine, Disopyramide, Dobutamine, Dofetilide, Dolasetron, Domperidone, Donepezil, Doripenem, Doxepin, Doxorubicin, Dronedarone, Droperidol, Duloxetine, E-4031, Ebastine, Eltrombopag, Encainide, Erythromycin, Etravirine, Everolimus, Famotidine, Felodipine, Fenspiride, Fexofenadine, Flecainide, Fluconazole, Fluoxetine, Fluvoxamine, Furosemide, Galantamine, Gatifloxacin, Gefitinib, Granisetron, Grepafloxacin, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyzine, Ibutilide,Imatinib, Imipramine, Irbesartan, Isradipine, Ivabradine, Ketanserin, Ketoconazole, Lacosamide, Lamivudine, Lamotrigine, Lapatinib, Levocetirizine, Levofloxacin, Levosimendan, Lidocaine, Linezolid, Loperamide, Lopinavir, Loratadine, Manidipine, Maprotiline, Maraviroc, Mefloquine, Mepivacaine, Mesoridazine, Methadone, Metoclopramide, Metoprolol, Metronidazole, Mexiletine, Mibefradil, Milrinone, Mitoxantrone, Mizolastine, Moxifloxacin, Nebivolol, Nelfinavir, Nicardipine, Nifedipine, Nifekalant, Nilotinib, Nilvadipine, Nimodipine, Nisoldipine, Nitrendipine, Nortriptyline, Ofloxacin, Olanzapine, Omecamtiv mecarbil, Ondansetron, Oseltamivir, Oxybutinin, Paliperidone, Palonosetron, Paroxetine, Pentamidine, Pentobarbital, Phenytoin, Pimozide, Piperacillin, Pitolisant, Prenylamine, Primidone, Procainamide, Procaine, Promethazine, Propafenone, Propranolol, Quetiapine, Quinidine, Quinine, Raltegravir, Ranolazine, Ribavirin, Ribociclib, Rilpivirine, Risperidone, Ritonavir, Ropivacaine, Roxithromycin, Rufinamide, Saquinavir, Sematilide, Sertindole, Sertraline, Sibutramine, Sildenafil, Silodosin, Sitaglitin, Solifenacin, Sotalol, Sparfloxacin, Sulpiride, Sunitinib, Tadalafil, Tamoxifen, Tedisamil, Telbivudine, Telithromycin, Terfenadine, Terodiline, Tetracaine, Thioridazine, Tolterodine, Trimipramine,Vandetanib, Vanoxerine, Vardenafil, Venlafaxine, Verapamil, Vernakalant, Voriconazole, Ziprasidone